Gamma delta T cells represent a new generation of cell therapy

The current engineered autologous alpha beta T cell products have shown significant efficacy in hematological malignancies; however comparable efficacy in solid tumors is yet to be proven. The cell platform and novel targeting approaches Adicet is developing are aimed at harnessing the tumor specific immunity of gamma delta T cells. The Company believes that gamma delta T cells may have a superior potential compared to alpha beta T cells to be active in both hematological cancers and solid tumors.

Potential Advantage of gamma delta T cells

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Gamma delta T cells have unique attributes that Adicet believes make them especially well-suited to be used for cancer therapy. The unique features of these cells combine adaptive (gamma delta TCR-mediated) and innate (NK-cell like) immunity to specifically recognize and eliminate tumor cells while sparing normal, healthy cells. Unlike alpha beta T cells, gamma delta T cells perform their tumor killing function in an MHC-independent manner and thus can be used in an allogeneic setting without the risk of causing Graft vs Host Disease (GvHD). Additionally, gamma delta T cells perform their immune surveillance by naturally homing to various tissues giving them a superior potential to alpha beta T cells to eradicate solid tumors in tissues. Adicet has demonstrated the cytotoxicity and anti-tumor activity of gamma delta T cells in vitro and in vivo in mouse models.

To date, the use of these cells has been limited because gamma delta T cells represent only a small fraction of the peripheral blood mononuclear cells (1-5%). Adicet has developed a proprietary and robust process to activate and expand different subsets of gamma delta T cells to numbers sufficient for utilization in the clinical setting.

Proprietary Cell Platform Process

Adicet has developed a proprietary cell platform process to activate, engineer and expand gamma delta T cells. The process allows for generation of cell banks that can be used to treat many patients.

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